Relationship Between Protein Oxidation Markers and Oxidative Stress Biomarkers

نویسنده

  • Silvia Clara Kivatinitz
چکیده

There is a general agreement (belief) that lipids are the pivotal element in inflammatory disease. One of the most studied topics is the connection between lipid oxidation and cardiovascular disease. In a very recent review, the introductory paragraphs states, after resuming the elements of the inflammatory response starting with stimulated endothelium displaying adhesive molecules for circulating leucocytes, lipid oxidation products formed by virtually every vascular cell type participate in orchestrating these processes and the inflammatory process is actively limited by activation of a resolution phase, often via generation of structurally specific oxidized lipids whose function is to orchestrate resolution of inflammation (McIntyre & Hazen 2010). Most of the knowledge involving lipid oxidation comes from “in vitro” studies and on supplementation trials with antioxidants like vitamins and anti-inflammatory drugs. Vitamins E and C are considered dietary antioxidants although mostly ex vivo measurements of lipid peroxidation have been performed (Hillstrom et al. 2003; Heinecke 2001). Quantifying “in vivo” lipid oxidation is not easy and several biomarkers of lipid peroxidation has been used like F2-isoprostanes, considered the most accurate way to measure oxidative stress “in vivo”, and as a risk factor for atherosclerosis and other diseases (Lawson et al. 1999). The secondary products of lipid peroxidation (LPO) the reactive carbonyl compounds, modify biologically essential molecules such as proteins and DNA bases (Yuan et al. 2006). Thus lipid oxidation processes in biological tissues may be more complicated since they contain a plethora of carbohydrates, proteins and lipids forming a complex matrix. In tissues, lipid oxidation can cause protein oxidation due to close interactions between lipids and proteins. LPO “in vivo” has been implicated as the underlying mechanisms in numerous disorders and diseases such as cardiovascular diseases, cancer, neurological disorders, and aging. Thus, when oxidative stress biomarkers are evaluated protein oxidation deserves consideration.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Effects of Taurine, Sestrin 2 and Phyllanthin on coronary artery diseases

Heart failure is a growing epidemic in the worldwide. Atherosclerosis is a major mechanism of cardiovascular disease including myocardial infarction and peripheral arterial disease. Moreover, it causes many diseases and deaths around the world. Atherosclerosis, like coronary artery disease (CAD), is associated with inflammation and oxidative stress. The current article has been collected the s...

متن کامل

Evaluation of Plasma Protein Oxidation Biomarkers in type 2 Diabetic Patients with Retinopathy

Objective: Retinopathy is a microvascular complication of diabetes and leading cause of blindness throughout the world. The proteins as the most chemical substances in the cells are exposed to oxidative damages of free radicals. The aim of this study was to evaluate the values of protein oxidation biomarkers in diabetic patients with retinopathy. Materials and Methods: This study was done on 3...

متن کامل

Phototherapy motivates protein and lipid oxidation in jaundiced term and late term neonates

Background: Hyperbilirubinemia is one of the most important complications encountered in neonatal units. It has been proposed that phototherapy yields oxidative stress. Therefore, this study was undertaken to survey the levels of antioxidant and oxidative stress in the serum of neonates before and after phototherapy. Methods: This study was performed on thirty-five healthy, late preterm (>35 w...

متن کامل

Sertraline alters level of adenosine deaminase activity, oxidative stress markers and cardiac biomarkers (homocysteine cardiac troponin I) in rats

The aim of this study is whether oxidative stress markers, homocysteine (Hcy), cardiac troponin I (cTnI) and the activity of adenosine deaminase (ADA) alter following administration of different doses of sertraline. Sixty male Wistar rats were assigned into four groups. Sertraline at doses of 20, 40 and 80 mg / kg / day) were administered to three groups through gastric gavage for 90 days. The ...

متن کامل

Novel Possible Biomarkers for the Cardiovascular Diseases Prognosis

Cardiovascular disease (CVD), especially heart failure (HF) as its common final pathway, is the leading cause of morbidity and mortality worldwide. Furthermore, oxidative and inflammatory processes represent fundamental underlying mechanisms for the development and progression of HF. Of interest, in recent years the development of markers with diagnostic and prognostic value for this pathology ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2012